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Evidence is increasing that every addiction without exception is related to difficulties with the brain's reward center, particularly the mesolimbic system. This area of the problem regulates reward responses in establishing food and sex, along with nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both when they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in responding to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to shed pounds can be very effective you can find combinations while watching FDA now awaiting approval. When dealing with fat loss and the those who go through it you should err to the side of caution and permit the FDA do its job and demand some research be done so your public understands the side effects and dangers of the medications before we drive them. Keep in mind that drug companies have been in business to generate money and that they would say almost anything to keep people on their medications. Researchers found out that participants using this drug for the year, lost excess weight within four weeks and have kept the load off throughout the 56 weeks from the study. Contrave is a combination of the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs that are made up of several active ingredient, which might make them more effective and safer. Combo-pilling may be the newest fad or in addition to this the newest to come under scrutiny and thus it is just more publicly known although in the past, comb-pilling to lose weight has been around since the eighties. The biggest reason that employing a combination of pills is now popular will be the fact that as of right now there aren't any long term prescription weightloss pills that have been licensed by the FDA besides orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications although some people might of the combinations have been rejected or have yet to be approved by the FDA. Seizures can be a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug also can raise blood pressure levels and heart rate, and really should not be used in individuals with a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure and heartbeat and must stop used in patients with uncontrolled high blood pressure, as well as by you are not heart-related and cerebrovascular (circulatory dysfunction impacting your brain) disease. Patients with a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes which has a boxed warning to alert medical professionals and patients for the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for smoking cessation. Acamprosate also works to eliminate the need to drink by reducing the the cravings for alcohol consumption. The major difference between Naltrexone and Acamprosate is always that Acamprosate is just not yet available in the United States. While it continues to be widely studied in Europe the actual chemical reason why it works is still unknown. It is thought that it interferes with receptors within the brain which process glutamate, which in effect alters just how ones body reacts to alcohol intake. Several of the European research has revealed a lot of promise with Acamprosate in that some of the patients had a practically double success rate for staying sober.